To defeat the boss effectively, it is recommended to employ a strategy that involves pushing back the boss and utilizing Smoke Bombs to blind the meats, especially the large one that attacks your frontline. This can be achieved by assigning a hero with a speed stat of 8 or higher. By doing so, you can effectively prevent the meat from applying blind and hunger effects, this will prevent you from losing entire turns. Additionally, it is crucial for your team to possess versatile damage capabilities. In other words, your heroes should be able to target and attack the boss at any rank because the boss will be constantly moving during the battle.